|
KMID : 1035620130010040400
|
|
Allergy Asthma & Respiratory Disease
2013 Volume.1 No. 4 p.400 ~ p.404
|
|
|
Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma
|
|
Shin Bo-Mi
Park So-Young
Yoon Sun-Young
Kim Tae-Bum
Cho Yoo-Sook
Moon Hee-Bom
Kwon Hyouk-Soo
Shin Eun-Hye
Yang Young-Joo
Cho Hyung-Jin
Jang Il-Young
Kang Dang-Uk
|
|
|
Abstract
|
|
|
|
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.
|
|
|
KEYWORD
|
|
|
DRESS syndrome, Dapsone, Pseudolymphoma, Drug hypersensitivity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|